Roles of RabGEF1/Rabex-5 domains in regulating FcεRI surface expression and FcεRI-dependent responses in mast cells
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165 words Text: 4999 words Running title: Role of RabGEF1 Vps9 domain in cell activation Category: Immunobiology Corresponding Author: Stephen J. Galli Department of Pathology, Stanford University School of Medicine, Stanford, CA 943055324, USA [email protected] Phone: (650) 723-7975 Fax: (650) 725-6902 Blood First Edition Paper, prepublished online March 6, 2007; DOI 10.1182/blood-2007-01-067363 Copyright © 2007 American Society of Hematology For personal use only. on October 24, 2017. by guest www.bloodjournal.org From
منابع مشابه
FcεRI expression and dynamics on mast cells.
Mast cells are key effector and immunoregulatory cells in IgE-associated immune responses, including allergic disorders. IgE antibodies bind to the high-affinity IgE receptor, FcεRI, expressed on the surface of mast cells; antigen-induced cross-linking of FcεRI-bound IgE molecules activates the mast cell to release an array of proinflammatory and immunomodulatory mediators. Because mast cells o...
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Rab5 is a small GTPase that regulates early endocytic events and is activated by RabGEF1/Rabex-5. Rabaptin-5, a Rab5 interacting protein, was identified as a protein critical for potentiating RabGEF1/Rabex-5's activation of Rab5. Using Rabaptin-5 shRNA knockdown, we show that Rabaptin-5 is dispensable for Rab5-dependent processes in intact mast cells, including high affinity IgE receptor (Fceps...
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Undoubtedly, mast cells play a central role in allergic processes. Specific allergen cross-linking of IgE bound to the high affinity receptors (FcεRI) on the mast cell surface leads to the release of preformed mediators and newly synthesized mediators, i.e. metabolites of arachidonic acid and cytokines. More and more data indicate that bacteria and viruses can influence FcεRI-dependent mast cel...
متن کاملProtein Profiling of the Secretome of FcεRI Activated RBL-2H3.1 Cells
Background: Secretory proteins of IgE receptor activated mast cells and basophils play a pivotal role in the generation of immediate and long term immune responses in allergy and type I hypersensitivity. Objective: The present study aims to generate a 2-D map and profile of proteins secreted from a high secretory variant of the rat basophilic leukemia cell line, RBL-2H3.1, which in view of the ...
متن کاملIMMUNOBIOLOGY Rabaptin-5 regulates receptor expression and functional activation in mast cells
Rab5 is a small GTPase that regulates early endocytic events and is activated by RabGEF1/Rabex-5. Rabaptin-5, a Rab5 interacting protein, was identified as a protein critical for potentiating RabGEF1/ Rabex-5’s activation of Rab5. Using Rabaptin-5 shRNA knockdown, we show that Rabaptin-5 is dispensable for Rab5dependent processes in intact mast cells, including high affinity IgE receptor (Fc RI...
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تاریخ انتشار 2007